ENTIRE Clinical & Research Center
Endocrine Neoplasia Translational Interdisciplinary REsearch Center
Research Projects
Spatial Transcriptomics in PPGL
We apply spatial transcriptomics to pheochromocytomas and paragangliomas, mapping gene activity within the tumor. This reveals how cancer, immune, and stromal cells interact, providing insight into tumor growth and potential therapeutic targets.
Identifying the role of metabolites in pseudohypoxic PNET
In VHL-related pancreatic neuroendocrine tumors, we study metabolic changes caused by pseudohypoxia and the buildup of oncometabolites. These findings highlight vulnerabilities in tumor metabolism that may be exploited for treatment.
Netrin–DCC Pathway in NET
We investigate how neuroendocrine tumors hijack the netrin–DCC signaling pathway to promote survival. Blocking this interaction is emerging as a promising therapeutic strategy.
Pseudohypoxia and Systemic Impact
We study how pseudohypoxia—a state where cells sense low oxygen despite normal levels—affects metabolism and the cardiovascular system, aiming to uncover its role in tumor biology and patient health.
