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Who are we?

The ENTIRE Center for patients with endocrine neoplasms was established in 2018 at the Chaim Sheba Medical Centre, a world-leading clinical and research center. The Center was founded by Dr. Amit Tirosh, an expert in endocrinology, endocrine cancer, and cancer genomics.

Our team provides state-of-the-art clinical care for patients with endocrine cancer and advocates performing molecular profiling as an integral part of the patient assessment. We combined our clinical section with the endocrine cancer genomics lab to accomplish our vision.

Our primary focus is the clinical management and molecular characterization of neuroendocrine tumors (NET). In particular, our team is known for its expertise in hereditary syndromes of NET, including multiple endocrine neoplasia (MEN) syndromes and von Hippel-Lindau disease (VHL).

New publication by our team: Medical management of VHL-related pancreatic tumors

Dr Helperin and Prof Tirosh published a thorough review on the available medical therapies for patients with VHL and pancreatic tumors. Please take a look, and contact us for questions!


In the news


Our Vision

To set a new standard of care for patients diagnosed with NET, and make what once considered utopic care level, attainable reality:


  • Reducing our patients' suffer and save them and their relative's lives by providing personal and compassionate clinical care, combined with state-of-the-art genomic assessment.

  • Developing targeted intervention for patients with hereditary endocrine cancer syndromes using state-of-the-art genomics studies.

  • Preventing cancer development in patients with NET, assess and advise their relatives on preventing disease propagation.


What we have done thus far

The ENTIRE Center provided clinical care for over 400 patients in 2020 with ~600 annual visits every year. Over 100 patients underwent full genomic assessment that yielded impactful clinical findings and was extended to include additional family members. Our clinical care is recognized by leading international societies and patients' organizations.


These are a few of our achievements:


  • Establishing an expert center in hereditary NET syndromes – The American VHL Alliance officially recognized our clinic as a Certified VHL Clinical Care Center. We are considered a referral center for patients with hereditary NET by patients organizations and professional societies.

  • Providing care everywhere for patients with hereditary NET – We initiated a unique traveling clinic to rural areas in Israel, such as Arab villages in Galilee. The clinic includes clinical evaluation and on-site genetic testing.


  • Performing genomic screening for every patient with NET – We perform a thorough genomic evaluation for every patient evaluated at our clinic, including patients with no civil status or insurance, at no cost.

  • Identifying treatment targets in VHL-related tumors using unique analysis of tumor metabolism products.

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